What is the advantage? Well the program, your email and all the settings are held in a single directory. It's easy to understand and easy to use.
Because this is a portable app you can:
The only gotcha is that you cant run two email clients (ie, this and outlook or this and another thunderbird client). You need to switch all your email to thunderbird (but thats a good idea anyway, thunderbird is much better than free outlook).
I recommend you switch to a thunderbird portable 100% and ditch all other email clients. IE: ONLY use thunderbird portable
Dont ever try and manually merge/copy email If you copy Thunderbird Portable to your laptop (to go overseas) then only use the laptop version until you copy it back to your desktop. Never run two different email clients at the same time. Email tends to deliver to which ever one reads the email first and merging them back is a nightmare. *ONLY USE ONE EMAIL CLIENT (or copy of thunderbird portable) AT ANY TIME* If you move your thunderbird portable to a laptop then dont use any other copy until you finish your trip and move thunderbird portable back to your desktop.
Think of this like getting your physical mail picked up by two people who hate each other and wont work together. Each of them keeps checking your letterbox for mail and grabbing anything they find.
Which one picks up any letter is totally random and if Fred picks up the letter then Sally wont ever know about it.
You only want *one* of these people picking up your letters at any time or things will get confused. It is ok to stop one and then start another (moving to your laptop while you go overseas), but having both trying to get your mail will just leave things in a mess.)